000			02617nam a22002177a 4500
003			OSt
005			20220816125245.0
008			121218b xxu||||| |||| 00| 0 eng d
020			_a9781848001244
040			_cKrishna
082			_a572.6 PAN
100			_aPanchenko, Anna.
245			_aprotein-protein interactions and networks : _bidentification, computer analysis and prediction / _c Anna Panchenko, Teresa Przytycka.
260			_aGermany : _bSpringer, _c2008.
300			_axi, 191 p. : _bill. ; _c24 cm.
504			_aincludes bibliographical references and index.
520			_aThe biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse and present numerous challenges to modern biomolecular research because of their complexity. Analysis of patterns and principles governing these interactions has prompted a rapid development of computational methods to identify protein interaction partners and to understand the roles of individual components of protein interaction networks in cell functions. This book integrates different approaches from bioinformatics, biochemistry, computational analysis and systems biology to offer the reader a comprehensive global view of the diverse data on protein-protein interactions and protein interaction networks. It brings together the descriptions of experimental techniques and expounds on different computational algorithms for protein network analysis and prediction of protein and domain interactions, with each chapter containing a description of the problem, a review of methods and algorithms, a list of resources and current conclusions. Features - Reviews experimental techniques for identification of protein interactions - Discusses protein interaction databases and methods of integrating data from diverse sources - Describes computational methods to predict protein and domain interaction partners - Explores the properties of interaction interfaces and highlights approaches to model the assembly of protein complexes - Examines the topological and dynamical properties of protein interaction networks and presents the tools for comparative analysis of these networks Written by leading experts, Protein-protein Interactions and Networks provides a broad, thorough and multidisciplinary coverage of this field. It will be invaluable to researchers from academia and the bioinformatics industry, as well as an excellent auxiliary text for graduate students studying the topic.
650			_aprotein-protein interactions and networks.
700			_aPrzytycka, Teresa.
942			_2ddc _cBK
999			_c3867 _d3867