000			01657nam a22002537a 4500
003			OSt
005			20220810123600.0
008			121212b xxu||||| |||| 00| 0 eng d
020			_a9783540878926
040			_cKrishna
082			_a579.77 FUS
100			_aFusetani, Nobuhiro.
245			_aMarine toxins as research tools / _cNobuhiro Fusetani, Kem, William.
260			_aJapan : _bSpringer, _c2009.
300			_axiv, 259 p. : _bill. ; _c24 cm.
504			_aincludes references and index.
520			_aMarine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools. Accordingly, interest in using such compounds as reagents has increased. Marine toxins are some of the most popular research tools and have already contributed much to our understanding of biological processes and disease mechanisms.
650			_aMarine toxins as research tools.
650			_aMarine toxins.
650			_aMarine biotechnology.
650			_aBiology _vResearch.
700			_aKem, William.
942			_2ddc _cBK
999			_c3452 _d3452